Leaving INTR@PID website

You are leaving INTR@PID Clinical Trials page. This link will take you to a website where our Terms of Use do not apply. Merck KGaA, Darmstadt, Germany has no control over the contents and policies of these sites or resources, and accepts no responsibility for your use of them.

Please Confirm

This website is an information resource intended only for Healthcare Professionals who are interested in information on Clinical Research and clinical trials conducted under a partnership between EMD Serono, the Healthcare business of Merck KGaA, Darmstadt, Germany, and GSK.

By clicking "I am a healthcare professional" you are declaring and confirming that you are a Healthcare Professional inside the U.S., and have read and understood this disclaimer.

Investigational clinical trials in lung cancer


LUNG 005

STAGE III

PHASE 2
RANDOMIZED

COMBINATION
THERAPY


INTR@PID LUNG 005 (NCT03840902) is a clinical trial assessing the efficacy and safety of bintrafusp alfa with chemoradiation followed by bintrafusp alfa versus placebo with chemoradiation followed by durvalumab for the treatment of stage III non-small cell lung cancer.1

 Status:

Now Enrolling


LUNG 024

STAGE IV

PHASE
1/2

COMBINATION
THERAPY


INTR@PID LUNG 024 (NCT03840915) is a clinical trial assessing the safety and efficacy of bintrafusp alfa with chemotherapy for the treatment of stage IV non-small cell lung cancer.2

 Status:

Active, Not Recruiting


LUNG 037

STAGE IV

PHASE 3
RANDOMIZED

MONOTHERAPY


INTR@PID LUNG 037 (NCT03631706) is a clinical trial assessing the efficacy and safety of bintrafusp alfa versus pembrolizumab for the treatment of stage IV non-small cell lung cancer that has high expression of PD-L1 in patients who have not received prior therapy.3

 Status:

Active, Not Recruiting


What is lung cancer?


Lung cancer is the most common type of cancer, with approximately 2.2 million people diagnosed worldwide in 20204


There are different types of lung cancer: non-small cell lung cancer and small cell lung cancer. Non-small cell lung cancer describes a group of different cancers that have similar treatment options and outlooks and is the most common type of lung cancer based on historical data

There are 2 main types of non-small cell lung cancer6:

1. Squamous cell carcinoma: cancer that forms in cells that line the lungs6

2. Nonsquamous carcinoma: any cancer that is not from a cell that lines the lungs. This includes multiple subtypes of cancer6-8:

  • Adenocarcinoma: cancer that forms in cells that line the alveoli which release substances like mucus6,7
  • Large cell (undifferentiated) carcinoma: cancer that forms in different types of large cells in the lungs6
  • Other: cancer subtypes that are less common, like adenosquamous carcinoma and sarcomatoid carcinoma6

  1. ClinicalTrials.gov. M7824 with cCRT in unresectable stage III non-small cell lung cancer (NSCLC). Accessed March 8, 2021. https://clinicaltrials.gov/ct2/show/NCT03840902. 
  2. ClinicalTrials.gov. M7824 in combination with chemotherapy in stage IV non-small cell lung cancer (NSCLC). Accessed March 8, 2021. https://clinicaltrials.gov/ct2/show/NCT03840915. 
  3. ClinicalTrials.gov. M7824 versus pembrolizumab as a first-line (1L) treatment in participants with programmed death-ligand 1 (PD-L1) expressing advanced non-small cell lung cancer (NSCLC). Accessed March 8, 2021. https://clinicaltrials.gov/ct2/show/NCT03631706. 
  4. Ferlay J, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Accessed 14 May 2021. https://gco.iarc.fr/today.
  5. Youlden DR, et al. J Thorac Oncol. 2008;3:819-31.
  6. American Cancer Society. What is lung cancer? Accessed March 8, 2021. https://www.cancer.org/cancer/lung-cancer/about/what-is.html. 
  7. National Cancer Institute. Non-small cell lung cancer treatment (PDQ®)–patient version. Accessed March 8, 2021. https://www.cancer.gov/types/lung/patient/non-small-cell-lung-treatment-pdq. 
  8. National Cancer Institute. NCI dictionary of cancer terms. Accessed March 8, 2021. https://www.cancer.gov/ publications/dictionaries/cancer-terms/def/adenocarcinoma. 
   

Explore the Knowledge Base