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Immuno-Oncology and Bintrafusp Alfa

What is immuno-oncology?

  • Immuno-oncology is an innovative approach to cancer therapy that utilizes the body’s own immune system to fight cancer
  • Advances in the field of immuno-oncology have allowed us to approach cancer therapy in a new and exciting way, with research suggesting we may be able to block immunosuppressive pathways in the tumor microenvironment1


What is bintrafusp alfa?

  • Bintrafusp alfa is an investigational bifunctional fusion protein currently being investigated for the treatment of various advanced solid tumors
  • Bintrafusp alfa is designed to simultaneously block two immunosuppressive mechanisms, TGF-β (transforming growth factor β) and PD-L1 (programmed death-ligand 1)2
  • By targeting these pathways, bintrafusp alfa aims to control tumor growth by potentially restoring and enhancing the anti-tumor response


Rationale for the dual targeting of TGF-β and PD-L1

Bintrafusp alfa is under clinical investigation and has not been proven to be safe and effective. There is no guarantee that bintrafusp alfa will be approved in the sought-after indication by any health authority worldwide.



1. Finn OJ. Ann Oncol. 2012;23(Suppl 8):6-9.

2. Lan Y, et al. Sci Transl Med. 2018;10:eaan5488.