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Investigational clinical trials in cervical cancer





INTR@PID CERVICAL 017 (NCT04246489) is a clinical trial assessing the efficacy and safety of bintrafusp alfa for the treatment of advanced unresectable and/or metastatic cervical cancer in patients who did not benefit from prior platinum based chemotherapy.1


Active, Not Recruiting





INTR@PID CERVICAL 046 (NCT04551950) is a clinical trial assessing the efficacy and safety of bintrafusp alfa with other anticancer therapies for the treatment of locally advanced or persistent, recurrent, or metastatic cervical cancer.2


Active, Not Recruiting

What is cervical cancer?

Cervical cancer is one of the most common cancers in women, with approximately 604,000 women diagnosed worldwide in 20203

There are 2 main types of cervical cancer4:

1. Squamous cell carcinoma: cancer that usually forms where the exocervix meet the endocervix, called the transformation zone4

2. Adenocarcinoma: cancer that usually forms in the endocervix4

Other less common types of cervical cancer include adenosquamous carcinoma and neuroendocrine tumors as well as undifferentiated carcinoma and gastric-type adenocarcinoma5,6

The cervix and cancer

  1. ClinicalTrials.gov. Bintrafusp alfa monotherapy in platinum-experienced cervical cancer. https://clinicaltrials.gov/ct2/show/NCT04246489. Accessed March 8, 2021.
  2. ClinicalTrials.gov. Bintrafusp alfa combination therapy in participants with cervical cancer (INTR@PID 046). https://clinicaltrials.gov/ct2/show/NCT04551950. Accessed March 8, 2021.
  3. Ferlay J, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Accessed 14 May 2021. https://gco.iarc.fr/today.
  4. American Cancer Society. What is cervical cancer? https://www.cancer.org/cancer/cervicalcancer/about/what-is-cervical-cancer.html. Accessed March 8, 2021.
  5. Marth C, et al. Ann Oncol. 2014;28(Suppl 4):iv72-83.
  6. Kojima A, et al. Am J Surg Pathol. 2007;31:664-72.

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