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CERVICAL CANCER

Investigational clinical trials in cervical cancer


CERVICAL 017

ADVANCED/
METASTATIC

PHASE 2

MONOTHERAPY


INTR@PID CERVICAL 017 (NCT04246489) is a clinical trial assessing the efficacy and safety of bintrafusp alfa for the treatment of advanced unresectable and/or metastatic cervical cancer in patients who did not benefit from prior platinum based chemotherapy.1

 Status:

Active, Not Recruiting


CERVICAL 046

ADVANCED

PHASE 1

COMBINATION
THERAPY


INTR@PID CERVICAL 046 (NCT04551950) is a clinical trial assessing the efficacy and safety of bintrafusp alfa with other anticancer therapies for the treatment of locally advanced or persistent, recurrent, or metastatic cervical cancer.2

 Status:

Active, Not Recruiting


What is cervical cancer?


Cervical cancer is one of the most common cancers in women, with approximately 604,000 women diagnosed worldwide in 20203


There are 2 main types of cervical cancer4:

1. Squamous cell carcinoma: cancer that usually forms where the exocervix meet the endocervix, called the transformation zone4

2. Adenocarcinoma: cancer that usually forms in the endocervix4

Other less common types of cervical cancer include adenosquamous carcinoma and neuroendocrine tumors as well as undifferentiated carcinoma and gastric-type adenocarcinoma5,6

The cervix and cancer


  1. ClinicalTrials.gov. Bintrafusp alfa monotherapy in platinum-experienced cervical cancer. https://clinicaltrials.gov/ct2/show/NCT04246489. Accessed March 8, 2021.
  2. ClinicalTrials.gov. Bintrafusp alfa combination therapy in participants with cervical cancer (INTR@PID 046). https://clinicaltrials.gov/ct2/show/NCT04551950. Accessed March 8, 2021.
  3. Ferlay J, et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Accessed 14 May 2021. https://gco.iarc.fr/today.
  4. American Cancer Society. What is cervical cancer? https://www.cancer.org/cancer/cervicalcancer/about/what-is-cervical-cancer.html. Accessed March 8, 2021.
  5. Marth C, et al. Ann Oncol. 2014;28(Suppl 4):iv72-83.
  6. Kojima A, et al. Am J Surg Pathol. 2007;31:664-72.
 

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