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BILIARY TRACT CANCER

Investigational clinical trials in biliary tract cancer


BTC 047

LOCALLY ADVANCED/ METASTATIC

PHASE 2

MONOTHERAPY


INTR@PID BTC 047 (NCT03833661) is a clinical trial assessing the efficacy of bintrafusp alfa for the treatment of locally advanced or metastatic biliary tract cancer in patients who did not benefit from prior chemotherapy.1

 Status:

Active, Not Recruiting


BTC 055

LOCALLY ADVANCED/ METASTATIC

PHASE 2/3
RANDOMIZED

COMBINATION
THERAPY


INTR@PID BTC 055 (NCT04066491) is a clinical trial assessing the safety and efficacy of bintrafusp alfa with chemotherapy versus chemotherapy for the treatment of locally advanced or metastatic biliary tract cancer in patients who have not received prior therapy.2

 Status:

Active, Not Recruiting


What is biliary tract cancer?


Biliary tract cancer is a rare type of cancer, with approximately 211,000 people diagnosed worldwide each year3,4


There are 4 types of biliary tract cancer5:

1. Intrahepatic cholangiocarcinoma: cancer that forms in the bile ducts within the liver5

2. Extrahepatic cholangiocarcinoma: cancer that forms in the bile ducts outside the liver5

3. Gallbladder cancer: cancer that forms in the gallbladder5,6

4. Ampullary cancer: cancer that forms in the ampulla of Vater, which connects the bile ducts to the small intestine5,7

The biliary tract and cancer


  1. ClinicalTrials.gov. M7824 monotherapy in locally advanced or metastatic second line (2L) biliary tract cancer (cholangiocarcinoma and gallbladder cancer). Accessed March 8, 2021. https://clinicaltrials.gov/ct2/show/NCT03833661. 
  2. ClinicalTrials.gov. Gemcitabine plus cisplatin with or without bintrafusp alfa (M7824) in participants with 1L biliary tract cancer (BTC). Accessed March 8, 2021. https://clinicaltrials.gov/ct2/show/NCT04066491. 
  3. Ouyang G, et al. Cancer. Published online March 22, 2021.
  4. NIH. Rare Diseases Act of 2002. Public L No. 107-280.
  5. Marcano-Boniilla L, et al. Chin Clin Oncol. 2016;5:61.
  6. Valle JW, et al. Ann Oncol. 2016;27:v28-37.
  7. John Hopkins Medicine. Ampullary cancer. Accessed March 8, 2021. https://www.hopkinsmedicine.org/health/conditions-and-diseases/ampullary-cancer. 
 

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